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Science 22 May 1970:
Vol. 168. no. 3934, pp. 996 - 998
DOI: 10.1126/science.168.3934.996
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Articles

Harderian Gland: Development and Influence of Early Hormonal Treatment on Porphyrin Content

Lennart Wetterberg 1, Arthur Yuwiler 1, Edward Geller 1, and Shawn Schapiro 2

1 Veterans Administration Center and Department of Psychiatry, University of California School of Medicine, Los Angeles 90024
2 Veterans Administration Hospital, San Fernando, California and Department of Psychiatry, University of California School of Medicine, Los Angeles 90024

The porphyrin content of the rat Harderian gland remains low until 12 days of age at which time both porphyrin content and concentration rapidly increase. Intraperitoneal administration of tetraiodothyronine (thyroxine) into newborn animals advances the appearance of porphyrin in the gland. Conversely, a single injection of cortisol acetate into newborns retards the appearance of porphyrin. The time of porphyrin appearance in the gland parallels the time for maturation of the evoked cortical response to visual stimulation in normal and hormone-treated animals.


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Thyroid Hormone Affects Secretory Activity and Uncoupling Protein-3 Expression in Rat Harderian Gland.
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Prenatal exposure to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether destroys the rodent Harderian gland.
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