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Science 15 May 1970:
Vol. 168. no. 3933, pp. 867 - 869
DOI: 10.1126/science.168.3933.867
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Articles

Norepinephrine Turnover and Metabolism in Rat Brain after Long-Term Administration of Imipramine

Joseph J. Schildkraut 1, Andrew Winokur 1, and Clarence W. Applegate 1

1 Department of Psychiatry, Harvard Medical School, Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Boston 02115

The rate of disappearance of intracisternally administered tritiated norepinephrine from rat brain is decreased after a single dose of the tricyclic antidepressant imipramine. During long-term administration of imipramine, however, the rate of disappearance of tritiated norepinephrine from brain gradually increases, and there is a concurrent decrease in the content of endogenous norepinephrine in brain. These findings may help to explain why antidepressant effects are observed clinically only after long-termn treatment with imipramine.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)