Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 May 1970:
Vol. 168. no. 3933, pp. 862 - 864
DOI: 10.1126/science.168.3933.862
Prev | Table of Contents | Next

Articles

Endotoxin: Stimulation of Bone Resorption in Tissue Culture

E. Hausmann 1, L. G. Raisz 2, and W. A. Miller 3

1 Department of Oral Biology, School of Dentistry, State University of New York, Buffalo 14226
2 Departments of Pharmacology and Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620
3 Department of Oral Biology, School of Dentistry, State University of New York at Buffalo

Bacterial endotoxins can stimulate the release of previously incorporated calcium-45 and tritiated proline from fetal rat bone in tissue culture. Endotoxin from Bacteroides melaninogenicus, an organism regularly found in the gingival crevice of man, produces a response similar to parathyroid hormone and is effective at doses as low as 0.1 microgram per milliliter. This response is inhibited by serum and dependent upon the presence of albumin. Endotoxins may play a role in the bone loss characteristic of human periodontal disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Hemoglobin Receptor Protein of Porphyromonas gingivalis Inhibits Receptor Activator NF-{kappa}B Ligand-Induced Osteoclastogenesis from Bone Marrow Macrophages..
Y. Fujimura, H. Hotokezaka, N. Ohara, M. Naito, E. Sakai, M. Yoshimura, Y. Narita, H. Kitaura, N. Yoshida, and K. Nakayama (2006)
Infect. Immun. 74, 2544-2551
   Abstract »    Full Text »    PDF »
Impaired Bone Resorption by Lipopolysaccharide In Vivo in Mice Deficient in the Prostaglandin E Receptor EP4 Subtype.
Y. Sakuma, K. Tanaka, M. Suda, Y. Komatsu, A. Yasoda, M. Miura, A. Ozasa, S. Narumiya, Y. Sugimoto, A. Ichikawa, et al. (2000)
Infect. Immun. 68, 6819-6825
   Abstract »    Full Text »    PDF »
Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often?.
J Ciampolini and K G Harding (2000)
Postgrad. Med. J. 76, 479-483
   Abstract »    Full Text »
Inhibition of Osteoblastic Cell Differentiation by Lipopolysaccharide Extract from Porphyromonas gingivalis.
H. Kadono, J.-I. Kido, M. Kataoka, N. Yamauchi, and T. Nagata (1999)
Infect. Immun. 67, 2841-2846
   Abstract »    Full Text »    PDF »
Periapical Inflammatory Responses and Their Modulation.
P. Stashenko, R. Teles, and R. D'Souza (1998)
Critical Reviews in Oral Biology & Medicine 9, 498-521
   Abstract »    Full Text »    PDF »
Factors in Virulence Expression and Their Role in Periodontal Disease Pathogenesis.
S. C. Holt and T. E. Bramanti (1991)
Critical Reviews in Oral Biology & Medicine 2, 177-281
   Abstract »    Full Text »    PDF »
The Role of Bacteroides Gingivalis in Periodontal Disease.
K. Okuda and I. Takazoe (1988)
Advances in Dental Research 2, 260-268
   Abstract »    PDF »
Microbial Pathogenicity Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in Human Periodontal Disease: Virulence Factors in Colonization, Survival, and Tissue Destruction.
J. Slots and R.J. Genco (1984)
Journal of Dental Research 63, 412-421
   PDF »
A Comparison of the Effects of Endotoxin Upon Fibroblast Proliferation and Macromolecular Syntheses.
R.E. Singer and W.G. Dutton (1979)
Journal of Dental Research 58, 1634-1639
   Abstract »    PDF »
Pharmacology and Therapeutics of Bone.
W.C. Sturtridge (1975)
Journal of Dental Research 54, B78-B86
   PDF »
Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes.
J. E. Horton, L. G. Raisz, H. A. Simmons, J. J. Oppenheim, and S. E. Mergenhagen (1972)
Science 177, 793-795
   Abstract »    PDF »
Role for Endotoxin and Complement in Periodontal Tissue Destruction.
R. Snyderman (1972)
Journal of Dental Research 51, 356-361
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)