Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 May 1970:
Vol. 168. no. 3933, pp. 854 - 856
DOI: 10.1126/science.168.3933.854
Prev | Table of Contents | Next

Articles

Catecholamine Biosynthesis in Brains of Rats Treated with Morphine

Doris H. Clouet 1 and Milton Ratner 1

1 New York State Research Institute for Neurochemistry and Drug Addiction, Ward's Island, New York 10035

In the brains of rats without tolerance to morphine, the accumulation of [14C]dopamine formed from [14C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Endomorphin System and Its Evolving Neurophysiological Role.
J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego (2007)
Pharmacol. Rev. 59, 88-123
   Abstract »    Full Text »    PDF »
Excretion of Catecholamine Metabolites During Methadone Maintenance and Withdrawal.
F. A. De Leon-Jones, J. M. Davis, E. E. Inwang, and H. Dekirmenjian (1983)
Arch Gen Psychiatry 40, 841-847
   Abstract »    PDF »
Endorphins in Psychiatry: An Overview and a Hypothesis.
K. Verebey, J. Volavka, and D. Clouet (1978)
Arch Gen Psychiatry 35, 877-888
   Abstract »    PDF »
Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration.
R Esposito and C Kornetsky (1977)
Science 195, 189-191
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)