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Science 15 May 1970:
Vol. 168. no. 3933, pp. 852 - 854
DOI: 10.1126/science.168.3933.852
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Articles

Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type

Nelson M. Vaz 1 and Bernard B. Levine 1

1 Department of Medicine, New York University School of Medicine, New York 10016

Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)