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Science 15 May 1970:
Vol. 168. no. 3933, pp. 841 - 843
DOI: 10.1126/science.168.3933.841
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Articles

Antagonism by DDT of the Effect of Valinomycin on a Synthetic Membrane

B. D. Hilton 1 and R. D. O'Brien 1

1 Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14850

The potassium conductance which is induced by 10-6 molar valinomycin in a lecithin-decane membrane is reversed by 3 x 10-6 molar DDT. Membranes not treated with valinomycin are not affected by DDT. This blockade of potassium conductance parallels the effect of DDT on axonic conduction. Dieldrin and lindane, whose physiological actions are in some ways like those of DDT, do not affect valinomycin-induced conductance of lecithin-decane membranes.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)