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Science 1 May 1970:
Vol. 168. no. 3931, pp. 591 - 592
DOI: 10.1126/science.168.3931.591
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Articles

Vitamin B12 Binders of Chicken Serum and Chicken Proventriculus Are Immunologically Similar

D. W. Sonneborn 1 and H. J. Hansen 1

1 Department of Biochemical Nutrition, Hofflmann-La Roche Inc., Nutley, New Jersey 07110

Two substances that bind vitamin Bl2 are found in chickens, one in the serum and another in the proventriculus. Their molecular weights, as estimated from gel filtration on Sephadex, are approximately 113,000 and 96,000, respectively. Antibody elicitedin ratsagainst the proventriculus binder reacts against both binders.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)