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Science 1 May 1970:
Vol. 168. no. 3931, pp. 588 - 589
DOI: 10.1126/science.168.3931.588
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Articles

Formation of Virus-like Particles by Bone Cells in Mice with a High Incidence of Spontaneous Leukemia

Brian H. Schofield 1, Charles P. Barrett 2, Stephen B. Doty 3, Frank H. J. Figge 4, and Robert A. Robinson 3

1 Department of Orthopaedic Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21205
2 Department of Anatomy, University of Maryland School of Medicine, Baltimore 21201
3 Johns Hopkins Hospital
4 University of Maryland

Bone samples from potentially leukemic and leukemic mice revealed numerous 90-to 110-nanometer particles morphologically identical to murine leukemia virus. Particles were observed budding from plasma membranes of osteocytes and osteoblasts but were most numerous in osteocyte lacunae. Particles were not observed in bone samples from mice which rarely develop leukemia.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)