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Science 24 April 1970:
Vol. 168. no. 3930, pp. 501 - 503
DOI: 10.1126/science.168.3930.501
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Articles

Brain Norepinephrine: Enhanced Turnover after Rubidium Treatment

Jon M. Stolk 1, William J. Nowack 1, Jack D. Barchas 1, and Stanley R. Platman 2

1 Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305
2 Department of Psychiatry, Downstate Medical School, State University of New York, Brooklyn

After biosynthesis of norepinephrine was inhibited, treatment of rats for 10 days with rubidium chloride (0.6 milliequivalent per kilogram of body weight) caused an increase in the rate of disappearance of norepinephrine in the brainstem but not in the telencephalon. Also the utilization of intracisternally injected tritiated norepinephrine was increased and was accompanied by a shift in the pattern of norepinephrine metabolism to normetanephrine. These data suggest that greater amounts of neuronally stored norepinephrine were released to central adrenergic receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurochemical, Endocrine, Pharmacological, and Genetic Studies.
(1974)
Arch Neurol 30, 8-23
   Abstract »    PDF »
Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement.
B. J. Carroll and P. T. Sharp (1971)
Science 172, 1355-1357
   Abstract »    PDF »
APPOINTMENTS.
(1970)
Science 168, 1192
   PDF »


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