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Science 24 April 1970:
Vol. 168. no. 3930, pp. 499 - 501
DOI: 10.1126/science.168.3930.499
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Articles

"Hypersexuality" and Behavioral Changes in Cats Caused by Administration of p-Chlorophenylalanine

James Ferguson 1, Steven Henriksen 1, Harry Cohen 1, George Mitchell 1, Jack Barchas 1, and William Dement 1

1 Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305, and Veterans Administration Hospital, Menlo Park Division, Menlo Park, California 94025

The behavior of 26 male cats was systematically observed before, during, and after daily administration of the tryptophan hydroxylase inhibitor, p-chlorophenylalanine. These observations established that "hypersexuality," increased aggression, and perceptual disorientation are sequelae of the chronic administration of the drug in cats.


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