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Science 24 April 1970:
Vol. 168. no. 3930, pp. 492 - 493
DOI: 10.1126/science.168.3930.492
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Articles

Mediation of Immunity to Tumor Isografts in Mice by Heterologous Ribonucleic Acid

Kenneth P. Ramming 1 and Yosef H. Pilch 1

1 Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014

The growth of tumor isografts in inbred mice is inhibited by intra-peritoneal injections of syngeneic spleen incubated, in vitro, with ribonucleic acid extracted from guinea pigs immunized with the same mouse tumor. This inhibition is partially tumor-specific. Treatment with ribonuclease abolishes the response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immune Cytolysis of Human Tumor Cells Mediated by Xenogeneic "Immune" RNA.
Y. H. Pilch, L. L. Veltman, and D. H. Kern (1974)
Arch Surg 109, 30-34
   Abstract »    PDF »
Recent Advances in Oncology.
D. L. MORTON, C. M. HASKELL, Y. H. PILCH, F. C. SPARKS, and W. D. WINTERS (1972)
Ann Intern Med 77, 431-454
   Abstract »    PDF »
Liver Histiocytes in Rejection of Tumor Cells: Preliminary Studies With the Isolated, Perfused Rodent Liver.
S. Draz, J. E. Byfield, P. Byfield, and E. W. Fonkalsrud (1971)
Arch Surg 102, 574-577
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)