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Science 24 April 1970:
Vol. 168. no. 3930, pp. 485 - 487
DOI: 10.1126/science.168.3930.485
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Articles

Colcemid Sensitivity of Fission Yeast and the Isolation of Colcemid-Resistant Mutants

Seymour Lederberg 1 and Gail Stetten 1

1 Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island 02912

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continiues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)