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Science 17 April 1970:
Vol. 168. no. 3929, pp. 385 - 386
DOI: 10.1126/science.168.3929.385
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Articles

Antimycin A: Stimulation of Cell Division and Protein Synthesis in Tetrahymena pyriformis

Charles Elson 1, Henrik A. Hartmann 2, Austin L. Shug 3, and Earl Shrago 4

1 Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
2 Department of Pathology, School of Medicine, University of Wisconsin
3 Veterans Administration Hospital and Institute of Enzyme Research, University of Wisconsin
4 Departments of Medicine and Nutritional Sciences, School of Medicine and College of Agricultural and Life Sciences, University of Wisconsin

Addition of antimycin A to a culture of Tetrahymena pyriformis caused an increase in cell division and protein synthesis in this ciliated protozoan. The antimycin effect is a function of the time of exposure to the antibiotic as well as of the age of the culture. A large accumulation of endoplasmic reticulum, reflecting increased protein synthesis, was visualized by electron microscopy in cells stimulated by the antimycin A.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Euglena gracilis: Formation of Giant Mitochondria.
R. Calvayrac, F. Van Lente, and R. A. Butow (1971)
Science 173, 252-254
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Science. ISSN 0036-8075 (print), 1095-9203 (online)