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Science 17 April 1970:
Vol. 168. no. 3929, pp. 382 - 384
DOI: 10.1126/science.168.3929.382
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Articles

Hormone-Sensitive Adenyl Cyclase: Cytochemical Localization in Rat Liver

Louis Reik 1, Gary L. Petzold 1, Joan A. Higgins 1, Paul Greengard 1, and Russell J. Barrnett 1

1 Departments of Anatomy and Pharmacology, Yale University School of Medicine, New Haven, Connecticut

An electron microscopic procedure has been developed, using rat liver, for the localization of hormone-sensitive adenyl cyclase. Isoproterenol-sensitive adenyl cyclase is located almost exclusively in the parenchymal cells. In contrast, glucagon-sensitive adenyl cyclase is located primarily in the reticulo-endothelial cells but is also present in parenchymal cells. Sodium fluoride-sensitive adenyl cyclase is found in both cell types.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Beta Adrenergic Stimulation of Endogenous Epidermal Cyclic AMP Formation.
J. A. Powell, E. A. Duell, and J. J. Voorhees (1971)
Arch Dermatol 104, 359-365
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Science. ISSN 0036-8075 (print), 1095-9203 (online)