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Science 10 April 1970:
Vol. 168. no. 3928, pp. 273 - 275
DOI: 10.1126/science.168.3928.273
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Articles

Histochemical Abnormalities of Skeletal Muscle in Patients with Acute Psychoses

W. King Engel 1 and Herbert Meltzer 2

1 National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014
2 Department of Psychiatry, University of Chicago, Pritzker School of Medicine, Chicago, Illinois

In 29 acutely psychotic patients (mostly schizophrenic), histochemical abnormalities of a myopathic type were demonstrated in skeletal muscle biopsies from 13 and were generally correlated with elevation of the "muscle" type isoenzymes of creatine phosphokinase in the patients' serum. The incidence was much higher than found in normal controls, hospitalized neurotic psychiatric patients, or parents of acutely psychotic patients. A diazo-coupling type of "alka-line phosphatase" reaction was particularly useful in identifying abnormal muscle fibers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of Isometric Exercise on Serum Creatine Phosphokinase Activity.
D. J. Goode and H. Y. Meltzer (1976)
Arch Gen Psychiatry 33, 1207-1211
   Abstract »    PDF »
Creatine Phosphokinase: Increased Activity of the Spinal Fluid in Psychotic Patients.
S. Vale, M. A. Espejel, F. Calcaneo, J. Ocampo, and J. Diaz-de-Leon (1974)
Arch Neurol 30, 103-104
   Abstract »    PDF »
Central Core Fibers in an Acutely Psychotic Patient: Evidence for a Neurogenic Basis for the Muscle Abnormalities in the Acute Psychoses.
H. Y. Meltzer (1972)
Arch Gen Psychiatry 27, 125-132
   Abstract »    PDF »
Creatine Phosphokinase and Psychosis.
D. E. Schweid, J. S. Steinberg, and H. S. Sudak (1972)
Arch Gen Psychiatry 26, 263-265
   Abstract »    PDF »
Serum Creatine Phosphokinase Activity in Newly Admitted Psychiatric Patients: Part II.
H. Y. Meltzer, R. Nankin, and J. Raftery (1971)
Arch Gen Psychiatry 24, 568-572
   Abstract »    PDF »
Possible Predictive Tests for Malignant Hyperthermia During Anesthesia.
J. A. Aldrete, A. Padfield, C. C. Solomon, and M. W. Rubright (1971)
JAMA 215, 1465-1469
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Muscle Abnormalities in Acute Psychoses.
H. Y. Meltzer and R. Moline (1970)
Arch Gen Psychiatry 23, 481-491
   Abstract »    PDF »
Histochemical Abnormalities of Skeletal Muscle in Acutely Psychotic Patients: Part II.
H. Y. Meltzer and W. K. Engel (1970)
Arch Gen Psychiatry 23, 492-502
   Abstract »    PDF »
Disruption of Myofibrils in the Skeletal Muscle of Psychotic Patients.
D. A. Fischman, H. Y. Meltzer, and R. W. Poppei (1970)
Arch Gen Psychiatry 23, 503-515
   Abstract »    PDF »


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