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Science 3 April 1970:
Vol. 168. no. 3927, pp. 133 - 135
DOI: 10.1126/science.168.3927.133
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Articles

Mixed Lymphocyte Cultures Produce Effector Cells: Model in vitro for Allograft Rejection

Pekka Häyry 1 and Vittorio Defendi 1

1 Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania

Mouse peripheral lymphocytes sensitized in vitro by culturing with allogeneic lymphocytes produced immunospecific destruction of target cells, as measured by release of chromium-51. Thus the sensitizing and effector phases of the cell-bound immune response can both be studied in an in vitro system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CD8 T Cells Specific for a Donor-Derived, Self-Restricted Transplant Antigen Are Nonpathogenic Bystanders after Vascularized Heart Transplantation in Mice.
A. Valujskikh, Q. Zhang, and P. S. Heeger (2006)
J. Immunol. 176, 2190-2196
   Abstract »    Full Text »    PDF »
Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive Phases.
F. H. Bach, M. Segall, K. S. Zier, P. M. Sondel, B. J. Alter, and M. L. Bach (1973)
Science 180, 403-406
   Abstract »    PDF »
Specificity of Allogeneic Cell Recognition by Human Lymphocytes in vitro.
D. C. Zoschke and F. H. Bach (1971)
Science 172, 1350-1352
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)