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Science 27 March 1970:
Vol. 167. no. 3926, pp. 1740 - 1742
DOI: 10.1126/science.167.3926.1740
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Articles

Habituation and Dishabituation of the GM-Withdrawal Reflex in Aplysia

Harold Pinsker 1, Irving Kupfermann 1, Vincent Castellucci 1, and Eiuc Kandel 1

1 Departments of Physiology and Psychiatry, New York University Medical School, and Public Health Research Institute of the City of New York, New York

A behavioral reflex mediated by identified motor neurons in the abdominal ganglion of Aplysia undergoes two simple forms of shortterm modification. When the gill-with-drawal reflex was repeatedly evoked by a tactile stimulus to the siphon or mantle shelf, the amplitude of the response showed marked decrement (habituation). After a period of rest the response showed spontaneous recovery. The amplitude of a habituated response was facilitated by the presentation of a strong tactile stimulus to another part of the animal (dishabituation). Many characteristics of habituation and dishabituation in Aplysia are similar to those in vertebrates.


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