Intestinal Enzymes: Indicators of Proliferation and Differentiation in the Jejunum
R. Fortin-Magana 1,
R. Hurwitz 1,
J. J. Herbst 1, and
N. Kretchmer 1
1 Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Division of Developmental Biology, Stanford University School of Medicine, Stanford, California
Some intestinal enZymes were assayed which were related to: (i) Cellular proliferation, for example, aspartate carbamoyltransferase, thymidine kinase, uridine kinase, and dihydroorotase; (ii) cellular differentiation, for example, lactase, invertase, maltase, alkaline phosphatase, and dipeptidase; and (iii) lysosomes, for example, beta-glucuronidase, acid beta-galactosidase, and acid phosphatase. These enzymatic determinations can be used to distinguish the crypt from the villus during healthy or diseased states.