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Science 20 March 1970:
Vol. 167. no. 3925, pp. 1627 - 1628
DOI: 10.1126/science.167.3925.1627

Articles

Intestinal Enzymes: Indicators of Proliferation and Differentiation in the Jejunum

R. Fortin-Magana 1, R. Hurwitz 1, J. J. Herbst 1, and N. Kretchmer 1

1 Lt. J. P. Kennedy, Jr., Laboratories for Molecular Medicine, Department of Pediatrics, Division of Developmental Biology, Stanford University School of Medicine, Stanford, California

Some intestinal enZymes were assayed which were related to: (i) Cellular proliferation, for example, aspartate carbamoyltransferase, thymidine kinase, uridine kinase, and dihydroorotase; (ii) cellular differentiation, for example, lactase, invertase, maltase, alkaline phosphatase, and dipeptidase; and (iii) lysosomes, for example, beta-glucuronidase, acid beta-galactosidase, and acid phosphatase. These enzymatic determinations can be used to distinguish the crypt from the villus during healthy or diseased states.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)