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Science 13 March 1970:
Vol. 167. no. 3924, pp. 1515 - 1517
DOI: 10.1126/science.167.3924.1515
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Articles

Bone Marrow and Spleen: Dissociation of Immunologic Properties by Cortisone

Mark A. Levine 1 and Henry N. Claman 1

1 Division of Clinical Immunology, Department of Medicine, University of Colorado Medical School, Denver 80220

Bone marrow and spleen cells react differently after treatment with cortisone acetate in vivo. Antibody-forming, hematopoietic, and proliferative responses of spleen cells are reduced, while bone marrow cell responses are not. The stimulation of spleen cells by phytohemagglutinin is abolished, but the response of marrow cells is enhanced. These reactions provide functional markers for the different cells involved in immunologic responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thymus-Derived Lymphocytes: Humoral and Cellular Reactions Distinguished by Hydrocortisone.
S. Segal, I. R. Cohen, and M. Feldman (1972)
Science 175, 1126-1128
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)