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Science 13 March 1970:
Vol. 167. no. 3924, pp. 1513 - 1514
DOI: 10.1126/science.167.3924.1513
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Articles

Heterozygous Beta Thalassemia: Balanced Globin Synthesis in Bone Marrow Cells

Elias Schwartz 1

1 Cardeza Foundation for Hematologic Research and Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania 19107

In two patients with heterozygous beta thalassemia the rates of synthesis of the alpha and beta chains of hemoglobin were equal in nucleated red cell precursors, although beta chain synthesis was reduced in peripheral blood reticulocytes. This finding suggests a relative instability of beta chain messenger RNA in beta thalassemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemoglobin Lepore Trait: Globin Synthesis in Bone Marrow and Peripheral Blood.
F. Gill, J. Atwater, and E. Schwartz (1972)
Science 178, 623-625
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Science. ISSN 0036-8075 (print), 1095-9203 (online)