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Science 13 March 1970:
Vol. 167. no. 3924, pp. 1508 - 1510
DOI: 10.1126/science.167.3924.1508
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Articles

Hyperbaric Oxygen: Effects on Metabolism and Ionic Movement in Cerebral Cortex Slices

Pierre Joanny 1, Jacques Corriol 1, and François Brue 2

1 Département de Physiologie, Faculté de Médecine, Université d'Aix-Marseille II, Boulevard Jean Moulin-13, Marseille (5°), France
2 Centre d'Etudes et de Recherches de Biophysiologie, Hôpital d'Instruction des Armées (Sainte Anne), Toulon-Naval-83, France

The incubation of slices of cerebral cortex under hyperbaric oxygen pressures from 1 to 10 atmospheres in the presence of radioactive glucose, pyruvate, succinate, fumarate, L-glutamate, and gamma-aminobutyric acid causes a marked diminution of tissue oxidative reactions. There is a simultaneous decrease in phosphocreatine and adenosine triphosphate, and a reduction of the apparent intracellular ionic gradients. The increase of lipid peroxides, measured directly, is attributed to the toxic effects of hyperbaric oxygen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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D. K. Mulkey, R. A. Henderson III, R. W. Putnam, and J. B. Dean (2003)
J Appl Physiol 95, 910-921
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Hyperbaric Oxygen.
B. G. Aoust and P. Joanny (1970)
Science 169, 704-705
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