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Science 13 March 1970:
Vol. 167. no. 3924, pp. 1499 - 1501
DOI: 10.1126/science.167.3924.1499
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Articles

Postnatal Muscle Fiber Assembly: Localization of Newly Synthesized Myofibrillar Proteins

Eugene Morkin 1

1 Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts

Addition of newly synthesized contractile proteins to striated muscle during postnatal life was studied by labeling young rat diaphragms in vitro with 3H-leucine and extracting the soluble proteins in glycerol. The grain distribution over glycerinated fibers in electron microscopic autoradiographs indicates that new myofibrillar proteins are added about the periphery of existing fibrils.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)