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Science 6 March 1970:
Vol. 167. no. 3923, pp. 1379 - 1380
DOI: 10.1126/science.167.3923.1379
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Articles

Polyinosinic Acid • Polycytidylic Acid: Inhibition of DNA Synthesis Stimulated by Isoproterenol

Frederic T. Serota 1 and Renato Baserga 1

1 Department of Pathology and Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140

Polyinosinic acid • polycytidylic acid (poly I • poly C) inhibits isoproterenol-stimulated DNA synthesis in salivary glands of mice. A single intraperitoneal injection of 250 micrograms of poly I • poly C inhibits the stimulation of DNA synthesis when given 10 minutes before isoproterenol or at any time during the 20-hour lag period between the injection of isoproterenol and the subsequent DNA synthesis. The inhibition caused by poly I • poly C is not due to a generalized toxic action but seems to be exerted through a relatively selective mechanism. Polyuridylic acid and diethylaminoethyl dextran are less effective in inhibiting isoproterenol-stimulated DNA synthesis.


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