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Science 13 February 1970:
Vol. 167. no. 3920, pp. 998 - 999
DOI: 10.1126/science.167.3920.998
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Articles

Proinsulin: Metabolic Effects in the Human Forearm

S. E. Fineberg 1 and Thomas J. Merimee 1

1 Boston University Medical Services, Boston City Hospital, Boston, Massachusetts 02118

Five subjects were studied by the forearm perfusion technique with proinsulin at a final plasma conceintration of 1.76 x 10-9 millimole per milliliter. Two of these subjects were studied with single-component insulin at a concentration of 1.96 x 10-9 millimole per milliliter. Proinsulin is, in general, biologically less potent than single-component insulin. In contrast to insulin, its effects upon adipose tissue are for the most part greater than upon muscle.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)