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Nanomedicine Summit 2008

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Science 13 February 1970:
Vol. 167. no. 3920, pp. 988 - 990
DOI: 10.1126/science.167.3920.988
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Articles

Placental Transfer of a Substituted Pteridine from Fetus to Mother

J. L. McNay 1 and P. G. Dayton 1

1 Departments of Medicine (Clinical Pharmacology) and Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322

In sito near-term sheep placentas transferred triamterene (2,4,7-triamino-6-phenyl-pteridine) from the fetus much more rapidly than to the fetus. This differential transfer effect may significantly influence the distribution of exogenous and endogenous compounds between the maternal and fetal compartments.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)