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Science 13 February 1970:
Vol. 167. no. 3920, pp. 1005 - 1007
DOI: 10.1126/science.167.3920.1005
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Articles

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

Virginia E. I 1 and Michael J. M 1

1 Metabolic Research Laboratory, Veterans Administration Hospital Department of Biochemistry, Bay College of Medicine, Houston, Te

Tetrahydropapaveroline is a benzyltetrahydroisoquinoline alkaloidderivative of the biogenic amine, dopnmine. Alcohol, by way of its primary metabolite, acetaldehyde, competitively inhibits nicotinamide-adenine Sinucleotide-linked aldehyde dehydrogenase and augments the formation of tetrahydropapaveroline in vitro. The limited capacity of brain to oxidize aldehydes may be of pharmacological importance because it facilitates the production of tetrahydropapaveroline in the presence of drugs which inhibit this enzyme.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase.
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ARE ANANDAMIDE AND CANNABINOID RECEPTORS INVOLVED IN ETHANOL TOLERANCE? A REVIEW OF THE EVIDENCE.
B. L. Hungund and B. S. Basavarajappa (2000)
Alcohol Alcohol. 35, 126-133
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Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine.
J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren (1999)
Pharmacol. Rev. 51, 341-396
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Cellular and molecular mechanisms of drug dependence.
G. Koob and F. Bloom (1988)
Science 242, 715-723
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Alcoholism and Genetics: The Sins of the Fathers.
D. W. Goodwin (1985)
Arch Gen Psychiatry 42, 171-174
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Naloxone and Alcohol Intoxication in the Dog.
H. Lignian, J. Fontaine, and R. Askenasi (1983)
Human and Experimental Toxicology 2, 221-225
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An Investigation of the Role of the Specific Opioid Antagonist Naloxone in Clinical Toxicology.
D.B. Jefferys and G.N. Volans (1983)
Human and Experimental Toxicology 2, 227-231
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Flushing Reactions: Consequences and Mechanisms.
J. K. WILKIN (1981)
Ann Intern Med 95, 468-476
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Dopamine-related tetrahydroisoquinolines: significant urinary excretion by alcoholics after alcohol consumption.
M. Collins, W. Nijm, G. Borge, G Teas, and C Goldfarb (1979)
Science 206, 1184-1186
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Partially modified retro-inverso-enkephalinamides: topochemical long-acting analogs in vitro and in vivo.
M Chorev, R Shavitz, M Goodman, S Minick, and R Guillemin (1979)
Science 204, 1210-1212
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Ethanol ingestion: differences in blood acetaldehyde concentrations in relatives of alcoholics and controls.
M. Schuckit and V Rayses (1979)
Science 203, 54-55
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Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain.
R. Myers and C. Melchior (1977)
Science 196, 554-556
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Opioid peptides endorphins in pituitary and brain.
A Goldstein (1976)
Science 193, 1081-1086
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Morphine and Ethanol: Selective Depletion of Regional Brain Calcium.
D. H. Ross, M. A. Medina, and H. Lee Cardenas (1974)
Science 186, 63-65
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Synergy of Ethanol and Putative Neurotransmitters: Glycine and Serine.
K. Blum, J. E. Wallace, and I. Geller (1972)
Science 176, 292-294
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Ethanol Preference in the Rat as a Function of Photoperiod.
I. Geller (1971)
Science 173, 456-459
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Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice.
A. Goldstein and B. A. Judson (1971)
Science 172, 290-292
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Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates.
G. Redmond and G. Cohen (1971)
Science 171, 387-389
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Alcohol Addiction and Tetrahydropapaveroline.
P. V. Halushka, P. C. Hoffmann, V. E. Davis, and M. J. Walsh (1970)
Science 169, 1104-1106
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Blood Concentrations of Acetaldehyde and Ethanol in Chronic Alcoholics.
E. Majchrowicz and J. H. Mendelson (1970)
Science 168, 1100-1102
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