Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 February 1970:
Vol. 167. no. 3919, pp. 896 - 898
DOI: 10.1126/science.167.3919.896
Prev | Table of Contents | Next

Articles

Dentin Matrix Transformation: Rapid Induction of Alkaline Phosphatase and Cartilage

Charles B. Huggins 1 and Marshall R. Urist 2

1 Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637
2 Department of Surgery, University of California, Los Angeles

An acid-insoluble fraction of rat dentin rapidly initiates a chain reaction in mesenchyma after allogeneic transplantation to the subcutaneous tissues. The tooth matrix induced alkaline phosphatase activity within 24 hours; cartilage appeared within 5 days; bone and bone marrow formed within 14 days. The induced cartilage disappeared within 5 weeks, but bone persisted at least 1 year.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Marshall R. Urist: A Renaissance Scientist and Orthopaedic Surgeon.
A. H. Reddi (2003)
J. Bone Joint Surg. Am. 85, 3-7
   Full Text »    PDF »
A New Biological Approach To Vital Pulp Therapy.
B. Rutherford and M. Fitzgerald (1995)
Critical Reviews in Oral Biology & Medicine 6, 218-229
   Abstract »    Full Text »    PDF »
Chondrocyte-like Colony Formation of Mesenchymal Cells by Dentin Extracts in Agarose Gel Culture.
K. Harada, S. Oida, S. Sasaki, and S. Enomoto (1990)
Journal of Dental Research 69, 1555-1559
   Abstract »    PDF »
Human Dentin Matrix Induces Cartilage Formation in vitro by Mesenchymal Cells Derived from Embryonic Muscle.
M.J. Somerman, M.A. Nathanson, J.J. Sauk, and B. Manson (1987)
Journal of Dental Research 66, 1551-1558
   Abstract »    PDF »
Subcutaneous Tooth Autografts in Rats.
S.H. Paik, J.E. Kennedy, and H.A. Zander (1972)
Journal of Dental Research 51, 1038-1042
   Abstract »    PDF »
Bone Morphogenetic Protein.
M. R. Urist and B. S. Strates (1971)
Journal of Dental Research 50, 1392-1406
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)