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Science 6 February 1970:
Vol. 167. no. 3919, pp. 869 - 870
DOI: 10.1126/science.167.3919.869
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Articles

L-Asparaginase-Induced Immunosuppression: Effects on Antibody-Forming Cells and Serum Titers

Asit K. Chakrabarty 1 and Herman Friedman 1

1 Department of Microbiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania

Treatment of mice with L-asparaginase from Escherichia coli resulted in a marked suppression of the immune response, as assessed both cellularly and humorally. Suppression occurred only when the enzyme was injected together with the sheep erythrocytes used as antigen. There was little or no effect when the enzyme was injected before the antigen. Simultaneous injection of asparagine prevented suppression, an indication that the effect of the enzyme was due to depletion of an amino acid probably essential for normal lymphoid cell function during antibody production.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
L-Asparaginase Induced Immunosuppression: Inhibition of Bone Marrow Derived Antibody Precursor Cells.
H. Friedman (1971)
Science 174, 139-141
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Science. ISSN 0036-8075 (print), 1095-9203 (online)