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Science 16 January 1970:
Vol. 167. no. 3916, pp. 294 - 297
DOI: 10.1126/science.167.3916.294
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Articles

Rhodanine: A Selective Inhibitor of the Multiplication of Echovirus 12

Hans J. Eggers 1, M. A. Koch 1, Arthur Furst 2, G. Doyle Daves Jr. 3, Joseph J. Wilczynski 3, and Karl Folkers 3

1 Institut für Virologie, Justus Liebig-Universität, Giessen, Germany
2 Institute of Chemical Biology, University of San Francisco, San Francisco, California
3 Stanford Research Institute, Menlo Park, California

A search for compounds which have previously unrecognized antiviral activity led to the discovery that rhodanine inhibits the multiplication of echovirus 12 and also the development of virus-induced morphologic changes. Eighteen derivatives and analogs of rhodanine were synthesized and tested against echovirus 12. These compounds were considerably less active than rhodanine or were inactive, and some of them were more toxic to the host cells than rhodanine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fatty Acid-Depleted Albumin Induces the Formation of Echovirus A Particles.
T. Ward, R. M. Powell, Y. Chaudhry, J. Meredith, J. W. Almond, W. Kraus, B. Nelsen-Salz, H. J. Eggers, and D. J. Evans (2000)
J. Virol. 74, 3410-3412
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)