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Science 2 January 1970:
Vol. 167. no. 3914, pp. 72 - 74
DOI: 10.1126/science.167.3914.72
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Articles

Metastasizing Mammary Carcinomas in Rats: Induction and Study of Their Immunogenicity

Untae Kim 1

1 Department of Pathology, Roswell Park Memorial Institute, Buffalo, New York 14203

Widely metastasizing mammary adenocarcinomas were isolated from methylcholanthrene-fed inbred young adult female W/Fu rats that had been splenectomized or thymectomized, and from those that had been both splenectomized and thymectomized. These tumors are transplantable and maintain their metastasizing capacity. They are either nonimmunogenic or less immunogenic than the nonmetastasizing conventional methylcholathrene-induced mammary tumors, which are highly immunogenic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors.
R. Bernacki and U Kim (1977)
Science 195, 577-580
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Science. ISSN 0036-8075 (print), 1095-9203 (online)