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Science 2 January 1970:
Vol. 167. no. 3914, pp. 59 - 60
DOI: 10.1126/science.167.3914.59
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Articles

Simian Virus 40 in Polio Vaccine: Follow-Up of Newborn Recipients

Joseph F. Fraumeni Jr. 1, Charles R. Stark 1, Eli Gold 2, and Martha L. Lepow 3

1 Epidlemiology Branch, Nationial Cancer Institute, Bethesda, Maryland 20014
2 School of Medicine, Case Western Reserve University, and Cleveland Metropolitan General Hospital, Cleveland, Ohio 44109
3 University of Connecticut Medical School, Hartford 06105

Soon after birth, when susceptibility to carcinogens should be enhanced, a group of children received oral polio vaccine which was later found to contain significant amounts of simian virus 40. Eight years after the incident, no cancer deaths have been observed among the vaccinated children, but continued surveillance is needed before concluding that simian virus 40 is innocuous to man.


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Simian Virus 40 Infection of Humans.
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Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.
J. Y.H. Kim, I. J. Koralnik, M. LeFave, R. A. Segal, L.-A. Pfister, and S. L. Pomeroy (2002)
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