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Science 26 December 1969:
Vol. 166. no. 3913, pp. 1624 - 1626
DOI: 10.1126/science.166.3913.1624
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Articles

Mouse Leukemia Virus Activation by Chemical Carcinogens

Howard J. Igel 1, Robert J. Huebner 2, Horace C. Turner 2, Paul Kotin 3, and Hans L. Falk 3

1 Children's Hospital, Akron, Ohio 44308
2 National Cancer Institute, Bethesda, Maryland 20014
3 National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Chemical Carcinogenesis by Viral Vaccines.
C. E. Whitmire and R. J. Huebner (1972)
Science 177, 60-61
   Abstract »    PDF »
Induction of Murine C-Type Viruses from Clonal Lines of Virus-Free BaALB/3T3 Cells.
S. A. Aaronson, G. J. Todaro, and E. M. Scolnick (1971)
Science 174, 157-159
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)