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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1548 - 1549
DOI: 10.1126/science.166.3912.1548
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Articles

Nalorphine: Increased Sensitivity of Monkeys Formerly Dependent on Morphine

Steven R. Goldberg 1 and Charles R. Schuster 1

1 Department of Pharmacology, University of Michigan Medical Schlool, Ann Arbor 48104

Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)