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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1546 - 1548
DOI: 10.1126/science.166.3912.1546
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Articles

Local Anesthetics: Significance of Hydrogen Bonding in Mechanism of Action

M. Sax 1 and J. Pletcher 1

1 Biocrystallography Laboratory, Veterans Administration Hospital, Pittsburgh, Pennsylvania 15240

The action of local anesthetics is considered in terms of their ability to function as the donor in a hydrogen bond. The formation of a hydrogen-bonded complex between the drug and an acceptor group on the neural membrane is suggested as a feature in the action of local anesthetics.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)