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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1535 - 1536
DOI: 10.1126/science.166.3912.1535
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Articles

Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

K. S. Chio 1, U. Reiss 1, B. Fletcher 1, and A. L. Tappel 1

1 Department of Food Science and Technology, University of California, Davis 95616

Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantitative measurement of the Schiff base product, a molecular damage site of lipid peroxidation which develops during some aging processes.


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The Influence of Aging on Lysosomal Acid DNase of the Rat Submandibular Gland.
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Effect of Dietary Selenite on Hepatic Organic Solvent-Soluble Lipofuscin Pigments.
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International Journal of Toxicology 5, 79-85
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Studies in Batten Disease: I. Peroxidase Deficiency in Granulocytes.
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Microsomal Lipid Peroxidation: Morphological Characterization.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)