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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1535 - 1536
DOI: 10.1126/science.166.3912.1535
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Articles

Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

K. S. Chio 1, U. Reiss 1, B. Fletcher 1, and A. L. Tappel 1

1 Department of Food Science and Technology, University of California, Davis 95616

Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantitative measurement of the Schiff base product, a molecular damage site of lipid peroxidation which develops during some aging processes.


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