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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1514 - 1516
DOI: 10.1126/science.166.3912.1514
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Articles

Choroid Plexus and Cerebrospinal Fluid Production

Thomas H. Milhorat 1

1 National Institutes of Health, Bethesda, Maryland 20014 and Children's Hospital, Washington, D.C. 20009

Acute progressive hydrocephalus occurred in 76 rhesus monkeys undergoing ventricular obstruction 2 to 6 months after choroid plexectomy and was only slightly less pronounced than in 73 nonplexectomized animals with similar ventricular obstructions. The composition of cerebrospinal fluid after choroid plexectomy was essentially normal. Experiments with ventricular perfusion techniques indicate only a slight reduction in cerebrospinal fluid production after choroid plexectomy. Thus, the choroid plexus is probably not tile sole or even the major source of cerebrospinal fluid within the primate ventricular system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cerebrospinal Fluid Production by the Choroid Plexus and Brain.
T. H. Milhorat, M. K. Hammock, J. D. Fenstermacher, D. P. Rall, and V. A. Levin (1971)
Science 173, 330-332
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Science. ISSN 0036-8075 (print), 1095-9203 (online)