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Science 12 December 1969:
Vol. 166. no. 3911, pp. 1435 - 1437
DOI: 10.1126/science.166.3911.1435
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Articles

Avoidance Learning: Long-Lasting Deficits after Temporal Lobe Seizure

James D. Belluzzi 1 and Sebastian P. Grossman 1

1 Department of Psychology, University of Chicago, Chicago, Illinois 60637

Microinjections of carbachol (carbamylcholine chloride) into the amygdaloid complex of rats produced behavioral and electrophysiological seizures which subsided within 24 hours. A persisting functional change caused a deficit in avoidance learning 1 to 3 weeks after the seizure. A cholinergic system is implicated by the fact that cholinergic blockade (scopolamine) of the amygdala during training reversed the effects of the seizures induced by carbachol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Interictal Behavior Syndrome of Temporal Lobe Epilepsy.
S. G. Waxman and N. Geschwind (1975)
Arch Gen Psychiatry 32, 1580-1586
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Science. ISSN 0036-8075 (print), 1095-9203 (online)