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Science 12 December 1969:
Vol. 166. no. 3911, pp. 1418 - 1420
DOI: 10.1126/science.166.3911.1418
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Articles

Prostaglandins E1 and E2 Antagonize Norepinephrine Effects on Cerebellar Purkinje Cells: Microelectrophoretic Study

Barry J. Hoffer 1, George R. Siggins 1, and Floyd E. Bloom 1

1 Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D. C. 20032

In microelectrophoretic experiments, prostaglandins E1 and E2 antagonize the reduction in discharge rate of cerebellar Purkinje cells produced by norepinephrine. Slowing of discharge evoked by 3',5'-adenosine monophosphate or gamma aminobutyric acid is not antagonized. These data provide the first indication that endogenous prostaglandins may physiologically function to modulate central noradrenergic junctions.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)