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Science 12 December 1969:
Vol. 166. no. 3911, pp. 1410 - 1412
DOI: 10.1126/science.166.3911.1410
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Articles

Intracranial Drug Implants: An Autoradiographic Analysis of Diffusion

Sebastian P. Grossman 1 and Walter E. Stumpf 2

1 Section of Biopsychology, University of Chicago, Chicago, Illinois 60637
2 Department of Pharmacology, University of Chicago

Labeled crystalline atropine, administered to the hypothlalamus of rats, remainted strictly localized in a sphere, 1.0 to 1.8 millimeters in diameter, ditring the first 3 minutes. A similar distribution obtained after 1 hour. At intermediate times, slightly elevated radioactivity, reflecting concentrations 2,000 to 10,000 times below behaviorally effective doses, was observed several millimeters from the implantation site.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)