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Science 5 December 1969:
Vol. 166. no. 3910, pp. 1276 - 1278
DOI: 10.1126/science.166.3910.1276
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Articles

Acetyl Coenzyme A Carboxylase: Filamentous Nature of the Animal Enzymes

Albrecht K. Kleinschmidt 1, Joel Moss 1, and M. Daniel Lane 1

1 Department of Biochemistry, New York University Schlool of Medicine, New York 10016

Acetyl coenzyme A carboxylases purified from several animal tissues exist as enzymatically active polymeric filaments of high molecular weight and have simillar electron microscopic, hydrodynamic, and catalytic properties. These filaments reversibly dissociate into inactive protomers of uniform size. Their re-assembly into catalytically active filaments is promoted by the presence of an allosteric activator.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Acetyl-CoA Carboxylase Isoforms by Pyridoxal Phosphate.
W. M. Lee, J. E. Elliott, and R. W. Brownsey (2005)
J. Biol. Chem. 280, 41835-41843
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A Novel Cold-Sensitive Allele of the Rate-Limiting Enzyme of Fatty Acid Synthesis, Acetyl Coenzyme A Carboxylase, Affects the Morphology of the Yeast Vacuole through Acylation of Vac8p.
R. Schneiter, C. E. Guerra, M. Lampl, V. Tatzer, G. Zellnig, H. L. Klein, and S. D. Kohlwein (2000)
Mol. Cell. Biol. 20, 2984-2995
   Abstract »    Full Text »    PDF »


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