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Science 21 November 1969:
Vol. 166. no. 3908, pp. 1023 - 1025
DOI: 10.1126/science.166.3908.1023
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Articles

Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase

Leila Diamond 1 and H. V. Gelboin 2

1 Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
2 Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014

Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Mechanisms of Cytochrome P450 Inhibition and Activation by alpha -Naphthoflavone.
A. P. Koley, J. T.M. Buters, R. C. Robinson, A. Markowitz, and F. K. Friedman (1997)
J. Biol. Chem. 272, 3149-3152
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Inhibition of human estrogen synthetase (aromatase) by flavones.
J. Kellis Jr and L. Vickery (1984)
Science 225, 1032-1034
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Skin Carcinogenesis: Cholesterol-5 agr, 6 agr-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light.
J. T. Chan and H. S. Black (1974)
Science 186, 1216-1217
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Arene Oxides: A New Aspect of Drug Metabolism.
D. M. Jerina and J. W. Daly (1974)
Science 185, 573-582
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Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs.
A. H. Conney and J. J. Burns (1972)
Science 178, 576-586
   Abstract »    PDF »
Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene.
J. P. Whitlock Jr., H. L. Cooper, and H. V. Gelboin (1972)
Science 177, 618-619
   Abstract »    PDF »
Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone.
H. V. Gelboin, F. Wiebel, and L. Diamond (1970)
Science 170, 169-171
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)