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Science 21 November 1969:
Vol. 166. no. 3908, pp. 1014 - 1015
DOI: 10.1126/science.166.3908.1014

Articles

Zinc-Deficient Embryos: Reduced Thymidine Incorporation

Helene Swenerton 1, Ruth Shrader 1, and Lucille S. Hurley 1

1 Department of Nutrition University of California, Davis 95616

The 12-day-old embryos of rats with a deficiency of zinc showed a reduced uptake of tritiated thymidine when compared with controls, as shown by liquid scintillation and autoradiography. The high incidence of gross congenital malformations resulting from zinc deficiency may thus be caused by DNA impaired DNA synthesis.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)