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Science 21 November 1969:
Vol. 166. no. 3908, pp. 1012 - 1013
DOI: 10.1126/science.166.3908.1012
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Articles

Changing Sensitivity of the Pubertal Gonadal Hypothalamic Feedback Mechanism in Man

Howard E. Kulin 1, Melvin M. Grumbach 1, and Selna L. Kaplan 1

1 Department of Pediatrics, University of California, San Francisco Medical Center, San Francisco 94122

Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estradiol Negative Feedback Regulates Nocturnal Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in Prepubertal Female Rhesus Monkeys.
M. E. Wilson, J. Fisher, and K. Chikazawa (2004)
J. Clin. Endocrinol. Metab. 89, 3973-3978
   Abstract »    Full Text »    PDF »
Neurobiological Mechanisms of the Onset of Puberty in Primates.
E. Terasawa and D. L. Fernandez (2001)
Endocr. Rev. 22, 111-151
   Abstract »    Full Text »
Late Effects: Disorders of Growth and Sexual Maturation Associated with the Treatment of Childhood Cancer.
T. Moshang JR and M. M. Lee (1988)
Journal of Pediatric Oncology Nursing 5, 14-19
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Clomiphene-Responsive Hypogonadism in Sickle Cell Anemia.
C. S. LANDEFELD, M. SCHAMBELAN, S. L. KAPLAN, and S. H. EMBURY (1983)
Ann Intern Med 99, 480-483
   Abstract »    PDF »
Olfactory Status and Response to Clomiphene in Male Gonadotrophin Deficiency.
C. R. HAMILTON JR., R. I. HENKIN, G. WEIR, and B. KLIMAN (1973)
Ann Intern Med 78, 47-55
   Abstract »    PDF »
Postmeningitic Selective Hypopituitarism With Suprasellar Calcification.
B. M. Sherman, P. Gorden, and G. di Chiro (1971)
Arch Intern Med 128, 600-604
   Abstract »    PDF »
The Hypothalamus Triggers Pubarche.
H. C. Faigel (1970)
Clinical Pediatrics 9, 254-255
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Science. ISSN 0036-8075 (print), 1095-9203 (online)