Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 November 1969:
Vol. 166. no. 3908, pp. 1002 - 1004
DOI: 10.1126/science.166.3908.1002
Prev | Table of Contents | Next

Articles

Immune Response in vitro: Independence of "Activated" Lymphoid Cells

Carl W. Pierce 1 and Baruj Benacerraf 1

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen-treated macrophages and lymphoid cells in cell culsters for only a finite time. During this critical period of interaction, lymphoid cells become "activated" and thereafter can develop into antibody-producing cells independently of native antigen, macrophages, and cell clusters.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Hermaphrocyte: A Suppressor-Helper T Cell.
R. K. Gershon, D. D. Eardley, K. F. Naidorf, and W. Ptak (1977)
Cold Spring Harb Symp Quant Biol 41, 85-91
   Abstract »    PDF »
Restoration of Antibody-Forming Capacity in Cultures of Nonadherent Spleen Cells by Mercaptoethanol.
C. Chen and J. G. Hirsch (1972)
Science 176, 60-61
   Abstract »    PDF »
Cell-Mediated Immunity Shown by Lymphocytes from the Respiratory Tract.
C. S. Henney and R. H. Waldman (1970)
Science 169, 696-697
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)