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Science 7 November 1969:
Vol. 166. no. 3906, pp. 768 - 769
DOI: 10.1126/science.166.3906.768
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Articles

Induction of Helical Arrays of Ribosomes by Vinblastine Sulfate in Escherichia coli

Elizabeth W. Kingsbury 1 and Herbert Voelz 1

1 Department of Microbiology, West Virginia University School of Medicine, Morgantown 26506

Physiological concentrations of vinblastine sulfate elicited ribosomal helices in large numbers in growing cultures of the osmotically sensitive mutant sud 24 and, after treatment with ethylenediaminetetraacetate, also in the K-12 strain. The helices were usually seen at the division plane and were often connected to the membrane. This method of induction of ribosomal helices offers a unique system for studying in vivo structure and function of the translational apparatus in relation to other cell components.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)