Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 November 1969:
Vol. 166. no. 3906, pp. 759 - 760
DOI: 10.1126/science.166.3906.759
Prev | Table of Contents | Next

Articles

Thiamine Release from Nerve Membranes by Tetrodotoxin

Y. Itokawa 1 and J. R. Cooper 1

1 Department of Pharmacology, Yale University, School of Medicine, New Haven, Connecticut 06510

Tetrodotoxin (3 x 10-8 molar) promoted the release of thiamine from perfused rat and frog nerve preparations in a manner similar to other neuroactive drugs. When the rats were injected with thiamine labeled with sulfur-35, analyses of brain, spinal cord, and sciatic nerve homogenates revealed labeled thiamine in membrane, synaptosomes, and mitochondrial subfractions. However, on incubation of these fractions with tetrodotoxin, thiamine was released only from the membrane fragments.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)