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Science 31 October 1969:
Vol. 166. no. 3905, pp. 627 - 628
DOI: 10.1126/science.166.3905.627
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Articles

Alcohol Metabolism: Role of Microsomal Oxidation in vivo

T. R. Tephly 1, F. Tinelli 1, and W. D. Watkins 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48104

A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mixed Function Oxidase and Ethanol Metabolism in Perfused Rat Liver.
I. E. Hassinen and R. H. Ylikahri (1972)
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Alcoholism, Alcohol, and Drugs.
E. Rubin and C. S. Lieber (1971)
Science 172, 1097-1102
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Reduced Nicotinamide-adenine Dinucleotide Phosphate Oxidase: Activity Enhanced by Ethanol Consumption.
C. S. Lieber and L. M. DeCarli (1970)
Science 170, 78-80
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Science. ISSN 0036-8075 (print), 1095-9203 (online)