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Science 24 October 1969:
Vol. 166. no. 3904, pp. 519 - 520
DOI: 10.1126/science.166.3904.519
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Articles

Cyclic Adenosine Monophosphate: Stimulation of Melatonin and Serotonin Synthesis in Cultured Rat Pineals

Harvey M. Shein 1 and Richard J. Wurtman 2

1 McLean Hospital Research Laboratory, Belmont, Massachusetts 02178, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
2 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge

Dibutyryl cyclic adenosine monophosphate, like norepinephrine, stimulates the synthesis of labeled melatonin and serotonin from tryptophan labeled with carbon-14 by rat pineals in organ culture. Unlike norepinephrine, dibutyryl cyclic adenosine monophosphate does not enhance the accumulation of labeled tryptophan or protein within the pineal. These findings are compatible with the hypothesis that cyclic adenosine monophosphate mediates some, but not all, of the effects of norepinephrine.


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