Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 17 October 1969:
Vol. 166. no. 3903, pp. 386 - 388
DOI: 10.1126/science.166.3903.386
Prev | Table of Contents | Next

Articles

Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate

John W. Olney 1 and Lawrence G. Sharpe 1

1 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110

In an infant rhesus monkey brain damage resulted from subcutaneously administered monosodium glutamate. Although a relatively high dose of monosodium glutamate was used, the infant was asymptomatic for a 3-hour observation period during which time hypothalamic neurons were undergoing a process of acute cell death. With the electron microscope it was observed that dendrites and cell bodies of neurons are the tissue components primarily affected in brain damage induced by monosodium glutamate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The blood-brain barrier and glutamate.
R. A Hawkins (2009)
Am. J. Clinical Nutrition 90, 867S-874S
   Abstract »    Full Text »    PDF »
Metabolic fate and function of dietary glutamate in the gut.
D. G Burrin and B. Stoll (2009)
Am. J. Clinical Nutrition 90, 850S-856S
   Abstract »    Full Text »    PDF »
Protein Phosphatase 1-Dependent Bidirectional Synaptic Plasticity Controls Ischemic Recovery in the Adult Brain.
G. F. Hedou, K. Koshibu, M. Farinelli, E. Kilic, C. E. Gee, U. Kilic, K. Baumgartel, D. M. Hermann, and I. M. Mansuy (2008)
J. Neurosci. 28, 154-162
   Abstract »    Full Text »    PDF »
Glutamine Improves Myocardial Function Following Ischemia-Reperfusion Injury.
G. Bolotin, J. Raman, U. Williams, E. Bacha, M. Kocherginsky, and V. Jeevanandam (2007)
Asian Cardiovasc Thorac Ann 15, 463-467
   Abstract »    Full Text »    PDF »
Extensive Gut Metabolism Limits the Intestinal Absorption of Excessive Supplemental Dietary Glutamate Loads in Infant Pigs.
M. J. Janeczko, B. Stoll, X. Chang, X. Guan, and D. G. Burrin (2007)
J. Nutr. 137, 2384-2390
   Abstract »    Full Text »    PDF »
Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons.
S. Sapoznik, M. Ivenshitz, and M. Segal (2006)
Learn. Mem. 13, 719-727
   Abstract »    Full Text »    PDF »
Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit.
R. Kuner, A. J. Groom, I. Bresink, H.-C. Kornau, V. Stefovska, G. Muller, B. Hartmann, K. Tschauner, S. Waibel, A. C. Ludolph, et al. (2005)
PNAS 102, 5826-5831
   Abstract »    Full Text »    PDF »
Altered Growth in Male Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) Heterozygous Mice: Involvement of PPAR{gamma} in a Negative Feedback Regulation of Growth Hormone Action.
J. Rieusset, J. Seydoux, S. I. Anghel, P. Escher, L. Michalik, N. Soon Tan, D. Metzger, P. Chambon, W. Wahli, and B. Desvergne (2004)
Mol. Endocrinol. 18, 2363-2377
   Abstract »    Full Text »    PDF »
Glutamate Transporters Prevent the Generation of Seizures in the Developing Rat Neocortex.
M. Demarque, N. Villeneuve, J.-B. Manent, H. Becq, A. Represa, Y. Ben-Ari, and L. Aniksztejn (2004)
J. Neurosci. 24, 3289-3294
   Abstract »    Full Text »    PDF »
Caspase-Dependent and Caspase-Independent Oligodendrocyte Death Mediated by AMPA and Kainate Receptors.
M. V. Sanchez-Gomez, E. Alberdi, G. Ibarretxe, I. Torre, and C. Matute (2003)
J. Neurosci. 23, 9519-9528
   Abstract »    Full Text »    PDF »
Distally Directed Dendrotoxicity Induced by Kainic Acid in Hippocampal Interneurons of Green Fluorescent Protein-Expressing Transgenic Mice.
A. A. Oliva Jr, T. T. Lam, and J. W. Swann (2002)
J. Neurosci. 22, 8052-8062
   Abstract »    Full Text »    PDF »
Slowly Inactivating Potassium Conductance (ID): A Potential Target for Stroke Therapy.
J. S. Bains, M. J. Follwell, K. J. Latchford, J. W. Anderson, and A. V. Ferguson (2001)
Stroke 32, 2624-2634
   Abstract »    Full Text »    PDF »
Glutamate antagonists: Deadly liaisons with cancer.
E. A. Cavalheiro and J. W. Olney (2001)
PNAS 98, 5947-5948
   Full Text »    PDF »
Na+-Dependent High-Affinity Glutamate Transport in Macrophages.
A.-C. Rimaniol, S. Haik, M. Martin, R. Le Grand, F. D. Boussin, N. Dereuddre-Bosquet, G. Gras, and D. Dormont (2000)
J. Immunol. 164, 5430-5438
   Abstract »    Full Text »    PDF »
The Safety Evaluation of Monosodium Glutamate.
R. Walker and J. R. Lupien (2000)
J. Nutr. 130, 1049
   Abstract »    Full Text »
Neurotransmitter Transporters in the Central Nervous System.
J. Masson, C. Sagne, M. Hamon, and S. E. Mestikawy (1999)
Pharmacol. Rev. 51, 439-464
   Abstract »    Full Text »    PDF »
Seizure-Induced Cell Death Produced by Repeated Tetanic Stimulation In Vitro: Possible Role of Endoplasmic Reticulum Calcium Stores.
M. R. Pelletier, J. S. Wadia, L. R. Mills, and P. L. Carlen (1999)
J Neurophysiol 81, 3054-3064
   Abstract »    Full Text »    PDF »
Reduction of Apurinic/Apyrimidinic Endonuclease Expression After Transient Global Cerebral Ischemia in Rats : Implication of the Failure of DNA Repair in Neuronal Apoptosis • Editorial Comment: Implication of the Failure of DNA Repair in Neuronal Apoptosis.
M. Kawase, M. Fujimura, Y. Morita-Fujimura, P. H. Chan, and C. Iadecola (1999)
Stroke 30, 441-449
   Abstract »    Full Text »    PDF »
Molecular Biology of Mammalian Plasma Membrane Amino Acid Transporters.
M. PALACIN, R. ESTEVEZ, J. BERTRAN, and A. ZORZANO (1998)
Physiol Rev 78, 969-1054
   Abstract »    Full Text »    PDF »
Excitatory Actions of GABA after Neuronal Trauma.
A. N. van den Pol, K. Obrietan, and G. Chen (1996)
J. Neurosci. 16, 4283-4292
   Abstract »    Full Text »    PDF »
Neuroexcitatory Amino Acids and Their Relation to Infarct Size and Neurological Deficit in Ischemic Stroke.
J. Castillo, A. Davalos, J. Naveiro, and M. Noya (1996)
Stroke 27, 1060-1065
   Abstract »    Full Text »
Glutamine or Glutamic Acid Effects on Intestinal Growth and Disaccharidase Activity in Infant Piglets Receiving Total Parenteral Nutrition.
D. G. Burrin, R. J. Shulman, M. C. Storm, and P. J. Reeds (1991)
JPEN J Parenter Enteral Nutr 15, 262-266
   Abstract »    PDF »
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
B Sommer, K Keinanen, T. Verdoorn, W Wisden, N Burnashev, A Herb, M Kohler, T Takagi, B Sakmann, and P. Seeburg (1990)
Science 249, 1580-1585
   Abstract »    PDF »
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.
J. Weiss, D. Hartley, J Koh, and D. Choi (1990)
Science 247, 1474-1477
   Abstract »    PDF »
Prehepatic Total Parenteral Nutrition in the Chair-adapted Primate.
R. M. Fairman, L. O. Crosby, T. P. Stein, G. P. Buzby, and J. L. Mullen (1983)
JPEN J Parenter Enteral Nutr 7, 237-243
   Abstract »    PDF »
alpha-Melanocyte-stimulating hormone: reduction in adult rat brain after monosodium glutamate treatment of neonates.
R. Eskay, M. Brownstein, and R. Long (1979)
Science 205, 827-829
   Abstract »    PDF »
Axon-sparing brain lesioning technique: the use of monosodium-L-glutamate and other amino acids.
E. Simson, R. Gold, L. Standish, and P. Pellett (1977)
Science 198, 515-517
   Abstract »    PDF »
Saltiness of Monosodium Glutamate And Sodium Intake.
L. M. Bartoshuk, W. S. Cain, C. T. Cleveland, L. S. Grossman, L. E. Marks, J. C. Stevens, and J. A. J. Stolwijk (1974)
JAMA 230, 670
   Abstract »    PDF »
Monosodium Glutamate: Absence of Hypothalamic Lesions after Ingestion by Newborn Primates.
W. A. Reynolds, N. Lemkey-Johnston, L. J. Filer Jr., and R. M. Pitkin (1971)
Science 172, 1342-1344
   Abstract »    PDF »
Monosodium Glutamate-Induced Brain Lesions: Electron Microscopic Examination.
E. A. Arees and J. Mayer (1970)
Science 170, 549-550
   Abstract »    PDF »
Monosodium Glutamate: Feeding of Large Amounts in Man and Gerbils.
G. Bazzano, J. A. D'Elia, and R. E. Olson (1970)
Science 169, 1208-1209
   Abstract »    PDF »
Monosodium Glutamate: Lack of Effects on Brain and Reproductive Function in Rats.
N. J. Adamo and A. Ratner (1970)
Science 169, 673-674
   Abstract »    PDF »
Amphetamine: Differentiation by d and I Isomers of Behavior Involving Brain Norepinephrine or Dopamine.
K. M. Taylor and S. H. Snyder (1970)
Science 168, 1487-1489
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)