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Science 10 October 1969:
Vol. 166. no. 3902, pp. 233 - 235
DOI: 10.1126/science.166.3902.233
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Articles

Androgen Accumulation and Binding to Macromolecules in Seminal Vesicles: Inhibition by Cyproterone

Judith M. Stern 1 and Arnold J. Eisenfeld 2

1 Institute of Animal Behavior, Rutgers University, Newark, New Jersey 07012
2 Departments of Pharmacology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510

Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)